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In type 2 diabetes, it often outperforms older therapies on both blood sugar and weight, which is why it is quickly becoming a backbone drug in highrisk metabolic patients. Better glycemic control cuts the risk of microvascular complications (eye disease, kidney damage, nerve damage) and macrovascular events (heart attack, stroke) over time. Fewer amputations, fewer cases of kidney failure, and fewer disabling strokes are core drivers of lost lifeyears and compressed healthspan that tirzepatide helps push back against. 3
It is a requirement
Cardiology 2010;116:178-82
Eating quickly is flagged separately as its own trigger, because it distends the stomach faster than the slowed emptying can handle
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