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Over time, excessive oxidative stress may contribute to the cellular wear and tear associated with ageing

doi: 10.1038/sj.bjp.0707462 51 JenhCHCoxMACuiLReichEPSullivanLChenSCet al

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The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme

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