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p38 MAPK has been implicated in a number of cellular processes, including the cell cycle, apoptosis, differentiation, neoplasm metastasis, angiogenesis and vasculogenesis (63)

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171 Although research into brain stimulation is in its early stages, case reports of successful treatment using stimulation to the brain cortex or deeper brain structures indicate the potential for this method to be helpful in patients with severe tinnitus that has not responded to other therapies