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GLP-1 is a hormone naturally produced in the body that helps signal fullness and influences how the body processes sugar

Alternative explanations include that GLP-1R in lamina IIIII neurons is a standby receptor for inducible GLP-1 expression under certain conditions (e.g., injury), or binds a yet unknown ligand

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[4] [5] The FDA label notes that tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

therefore, diligent postmarketing surveillance to elucidate the risk of medullary thyroid carcinoma (MTC) is ongoing