does glp 1 affect bone density GLP-1s and loss! Does GLP-1 Affect Bone Density?

Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, Snyder SH

Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic

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The studies excluded patients on any other migraine preventive treatment, patients with medication overuse headache, patients with ECG abnormalities compatible with an acute cardiovascular event and patients with a history of stroke, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass grafting, deep vein thrombosis, or pulmonary embolism within 6 months of screening

10.1002/adma.201802244 74 XiongY.-X.XiaoC.LiZ.-F.YangX.-L