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Research published in eBioMedicine confirmed that cagrilintide lowers body weight specifically through brain amylin receptors 1 and 3 (AMY1R and AMY3R), and these are distinct from the receptors that GLP-1 agonists activate
Collectively, these findings highlight the dual capacity of GLP-1 RAs to reduce FBM while supporting skeletal muscle health, a distinction of clinical importance in the long-term management of obesity
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Yang X, Ren H, Li Z, Fu J
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