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Regarding CSSS, there was a significant decrease in CSSS in all studied patients after intervention (the range decreased from an initial of 19118 to 1099 after intervention with a P-value of 0.025)

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That study demonstrated that constructing pathway-based comorbidity networks using high-centrality (hub) pathways can uncover key molecular interactions that may be overlooked by traditional transcriptomic analyses, particularly in the absence of human comorbid datasets

doi:10.3389/fendo.2019.00155 [5] Drucker D