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Vitamin B12 injections are medically necessary when a patient has severe deficiency, neurological symptoms requiring rapid correction, or a condition that prevents adequate oral absorption
The 2026 Sports Medicine and JAAOS Global Research and Reviews papers (PMID 41966639, PMID 41490200) place multiple compounds including this one into the wider research context of unapproved compounds under active investigation, with attention to both the mechanism findings and the regulatory framing that researchers consulting these reviews should weigh equally
(Generally, most people can supplement with thiamine without prior testing.) The supplements I have taken for thyroid fatigue and recommend are the highly absorbable Benfotiamine by Rootcology, and BenfoMax by Pure Encapsulations
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