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Picomolar to nanomolar activity suggests high receptor affinity and potent biological signalling, which is encouraging for topical delivery where only a fraction of applied compound reaches the follicle

c , Fat mass (g g body weight (BW) 1 ), d , plasma insulin concentration, e , liver mass (g g BW 1 ), and f , H&E staining of liver sections (Scale bar = 100 m, n = 3 mice per group)

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