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Beyond immune exclusion, immune function is actively suppressed by tumors: elevated N- acetylaspartate (NAA) production disrupts the immunological synapse in CD8 + T and NK cells (178), while FGF21 derived from cancer cells rewires cholesterol metabolism toward inducing T-cell exhaustion (155)

Weight loss medications mimic hormones in the body that affect appetite regulation, helping patients feel fuller from smaller portions and making it easier to reduce calorie intake

Some medical histories, like thyroid cancer or severe gastrointestinal diseases, may affect eligibility, and alternative treatments can be discussed

This helps prevent serious problems

Am J Geriatr Psychiatry