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If flu-like symptoms persist beyond the expected titration phase without improvement, or worsen over time, this warrants medical review to exclude other causes and consider whether the medication is appropriate for continued use
Unlike semaglutide (Ozempic/Wegovy), which activates a single receptor (GLP-1), or tirzepatide (Mounjaro/Zepbound), which activates two (GLP-1 + GIP), retatrutide activates three metabolic receptors at once: GLP-1 slows gastric emptying, suppresses appetite, improves insulin response GIP additional insulin-sensitivity and appetite effects Glucagon boosts energy expenditure and lipolysis (this is the new mechanism) The glucagon component is what makes retatrutide unique
These injections mimic a natural hormone in the body
Tell your doctor or pharmacist if you notice any of the following and they worry you: Diarrhoea Nausea Headache Vomiting Dizziness Acne Skin rash Pain or redness at the injection site Feeling hot or cold
FIGURE 1 In K cells, regulatory factor X6 (Rfx6) is a transcription factor that binds to the Gip promoter to increase Gip mRNA expression (Suzuki et al., 2013)
