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The current evidence strongly suggests these medicines are safe regarding thyroid cancer risk when prescribed appropriately
Novo Nordisk may have first-mover advantage in the oral space, with oral Wegovy (obesity) and Rybelsus (T2D, launched 2019), but orforglipron is expected to outperform these on-market semaglutide options for a number of reasons: superior HbA1c reduction and weight loss
A school of medical thought supports patients gradually ending their use, but Hong said obesity is generally considered a chronic condition that requires indefinite treatment
Effective dosing requires matching formulation strength to metabolic capacity
The precise physiological mechanisms responsible for heart rate elevation are not fully elucidated, but several hypotheses have been proposed: Sympathetic nervous system activation may occur as GLP-1 receptors are present in areas of the brain that regulate autonomic function
