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Similar content being viewed by others Subjects Introduction Familial exudative vitreoretinopathy (FEVR) is a hereditary eye disease (0.46% in Chinese newborns) driven primarily by mutations in the Norrin/-catenin (~40% of cases, FZD4 , LRP5 , NDP , TSPAN12 , or CTNNB1 ) 1,2 , as well as the cadherin/catenin ( CTNNA1 and CTNND1 ) 3,4 and Jag1/Notch signaling ( JAG1 ) 5