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Medication interactions and timing Avoid changing oral or injectable medicines immediately after a B12 shot without seeking clinical advice

The standard initial loading dose is 1,000 mcg administered intramuscularly (IM) once weekly for 4 weeks

However, high doses of vitamin B12, such as those used to treat a deficiency, might cause: Headache Nausea and vomiting Diarrhea Fatigue or weakness Its important to note that these side effects are generally mild and temporary