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David: Wow, Gina, I have to say you really have been doing your homework

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However, the long-term cardiovascular and renal benefits need to be carefully evaluated against the risk of DKA

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According to him 'this was contrary to everything that was then believed about the physiological role of glucagon in glucose homeostasis if indeed there was one.' Just a couple of years before, Yalow and Berson had detected larger than normal rises in the plasma insulin levels in insulinoma patients injected with glucagon, but concluded this was due to insulin released from the liver