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In PTs reported, the most frequently reported were nausea, vomiting, diarrhoea, etc., consistent with the most commonly associated SOC with adverse effects being the gastrointestinal tract (Table 3)

If you take birth control pills, inform your provider so backup contraception can be recommended during the first 4 weeks of semaglutide therapy and anytime your dose increases

Markers of systemic inflammation including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) also improved with GLP-1 drugs

A 2025 study found that people taking GLP-1 medications performed significantly worse on taste tests across all five basic tastes, sweet, salty, sour, bitter and umami, while their sense of smell remained largely unchanged