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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

Some peptides regulate the hypothalamic-pituitary-gonadal axis more directly, optimizing gonadotropin release patterns and normalizing downstream hormone production

Roche, Mannheim, Germany)

Common sites for self-injection are the thigh (vastus lateralis muscle) or the hip area