It competes with nicotinamide (NAM) for the active binding site of NNMT, preventing the enzyme from catalyzing the transfer of a methyl group from SAM to NAM
Its a natural way to support gut health and improve gut health
IGF-1 can act over its putative receptor (IGF-1R) or it can also bind to the insulin receptor (IR), albeit with less affinity [9]
doi:10.1111/j.1365-2982.2010.01476.x Panjwani N, Mulvihill EE, Longuet C, et al
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