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Berk M, et al
We note that although the chondroprotective effects of metformin was clearly attenuated in Nrf2 KO mice, micro-CT analysis revealed some variability in trabecular bone parameters, including occasional increases in subchondral trabecular bone amounts in Nrf2 KO OA mice (Fig
However, major uncertainties remain regarding environmentally relevant exposure levels, long-term human effects, and the translational relevance of current experimental findings
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