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I think what the potential efficacy of GLP-1 agonists for substance-use disorders is telling us, is suggesting is that there may be this kind of final common pathway, this core underlying biology of desire, of wanting things that may transcend food or alcohol or other things and may reflect something fundamental about the way the brain processes these feelings

Correspondingly, this will enable the screening or design of compounds targeting these distinct nodes

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Recently it has become apparent that immune dysregulation rather than an overactive immune response per se can play a significant role in disease pathology

A patient who might be a good candidate for Contrave often struggles intensely with food cravings and what we call 'hedonic eating'eating for pleasure rather than hunger