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For persistent constipation, prescription-strength options like linaclotide or lubiprostone may be necessary when over-the-counter solutions are insufficient
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Future studies aiming to assess the duration of the therapeutic efficacy and the optimal dose in larger populations, possibly with longer follow-up periods, are required
Therefore, ID impairs PHD activity, leading to the accumulation of HIF-1 (109)
It also has good tolerance to oxygen and light and does not require special inert-gas protection or light-proof packaging
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