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Tirzepatide did not demonstrate detectable attenuation of weight reduction-induced decreases in sleeping or 24-h energy expenditure, but there was a reduction in respiratory exchange ratio in the tirzepatide treatment arm compared with that in the placebo arm, consistent with an increase in fat oxidation
Retatrutide is a GLP-1/GIP/glucagon triple agonist originally developed for obesity treatment
It belongs to a novel class of agents known as triple agonists, targeting three incretin and metabolic receptors simultaneously: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
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Understanding GLP-1 Medications Both tirzepatide and semaglutide belong to a class of medications called GLP-1 receptor agonists, but theres an important distinction that makes tirzepatide potentially more effective for some patients
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