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In animal models of heart failure induced by high-frequency pacing, ischaemia, and obesity, GLP-1RAs inhibit left ventricular remodelling and improve left ventricular contractility and diastolic function through anti-inflammatory effects, cardiomyocyte apoptosis inhibition, and glucose metabolism enhancement in cardiomyocytes [38,39,40]
Tumor Risk: The Dark Side of Growth Promoting Effects Cell proliferation and anti apoptotic effects IGF-1 LR3 activates the IGF-1R/PI3K/Akt pathway, inhibits the expression of key apoptotic proteins such as Caspase-3 and Bax, and promotes the synthesis of cell cycle proteins such as Cyclin D1, thereby accelerating cell proliferation
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In addition to external factors such as UV radiation, the tumour microenvironment can contribute to melanoma progression, invasion and metastasis
Table 4 demonstrates the detailed result of this analysis
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