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For patients undergoing elective procedures, most can continue GLP-1 receptor agonists like Zepbound according to current multi-society guidance

siRNA targeting LRP5 (GGACAGACUCAGAGAGACCAA) was transferred into the BMSCs with the help of Lipofectamine 3000 (Invitrogen, United States), and all operations were carried out under the manufacturers instructions

Around 50% of people discontinue GLP-1 RAs within the first year, yet these drugs offer significant benefits in both type 2 diabetes and obesity

Still, semaglutide remains a highly effective and accessible therapy, with a strong safety record and broader real-world use