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Plasma exposure of mice to both 1 and 2 is compatible with observed efficacy and no overt toxicity was observed
Cancer cell membrane-coated ZnO nanoparticles dissolve in the acidic lysosome, simultaneously releasing siRNA payloads and generating zinc ions that induce osmotic pressure and rupture the organelle from within, ensuring cytosolic escape [20]
Values represent uptake after subtraction of background signal from empty liposome control
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