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Participants were randomly assigned to receive either semaglutide (0.25 mg/week for 4 weeks, 0.5 mg/week for 4 weeks, and 1.0 mg for 1 week) or placebo over nine weeks of outpatient treatment
Semaglutide works by mimicking the GLP-1 hormone, slowing gastric emptying, stimulating insulin secretion, and lowering glucagon levels
For example, sudden vision loss or a painless, rapid drop or dimming of vision in one eye could be a sign of a rare optic nerve issue, such as NAION
A few important notes about titration
doi: 10.1016/j.exger.2020.110888
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