It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade
PMCID: PMC7108996 Andersen NB, Malmlf K, Johansen PB, Andreassen TT, rtoft G, Oxlund H
335 In experimental settings, conditional knockout of K ir 4.1 results in epileptic phenotype
Many of these new substances appear so fast and with little efficacy support in the literature making it difficult for anti-doping authorities to properly evaluate and consider if they are a problem from the standpoint of performance enhancement
Pace A, Savarese A, Picardo M, Maresca V, Pacetti U, Del Monte G,