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REDEFINE 2 (With Type 2 Diabetes)# 1,206 patients randomized to CagriSema (n=904) or placebo (n=302)

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Cagrilintide = once weekly

FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture