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In vitro studies support these findings, showing that smooth muscle cells derived from varicose veins display marked dedifferentiation, enhanced proliferative and migratory capacity, increased matrix metalloproteinase-2 (MMP-2) production, and elevated collagen synthesis, accompanied by downregulation of contractile phenotype markers, collectively promoting extracellular matrix turnover and venous wall remodeling, thereby weakening mechanical resistance to chronic pressure (45)

J., Clayton, C

However, the role and mechanism of IAA neurotoxicity remain unclear

Children of 5 years who weigh 50 lbs, the recommended dose should not exceed 75-100mg (1.5 to 2mg/lb)

Inoue M, Kinne R, Tran T, Arias I: Glutathione transport across hepatocyte plasma membranes