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This means your body burns more calories just by digesting them: Protein: Swap fatty meats for chicken breast or fish
Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks
More specifically, the FDA label states that these medications may lead to thyroid C-cell tumors
But it is still not a simple one-size-fits-all substitution
Whilst this route is essential for treating pernicious anaemia and other malabsorption conditions, it can produce serum B12 levels far exceeding physiological requirements
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